Basic Research

 

Selected publications by the Zymetech research group in collaboration with the Science Institute University of Iceland, University of Iceland and international collaborators.

1. Asgeirsson, B. and J.B. Bjarnason, Structural and kinetic properties of chymotrypsin from Atlantic cod (Gadus morhua). Comparison with bovine chymotrypsin. Comp Biochem Physiol B, 1991. 99(2): p. 327-35.
2. Asgeirsson, B. and J.B. Bjarnason, Properties of elastase from Atlantic cod, a cold-adapted proteinase. Biochim Biophys Acta, 1993. 1164(1): p. 91-100.
3. Asgeirsson, B., J.W. Fox, and J.B. Bjarnason, Purification and characterization of trypsin from the poikilotherm Gadus morhua. Eur J Biochem, 1989. 180(1): p. 85-94.
4. Benjamin, D.C., S. Kristjansdottir, and A. Gudmundsdottir, Increasing the thermal stability of euphauserase. A cold-active and multifunctional serine protease from Antarctic krill. Eur J Biochem, 2001. 268(1): p. 127-31.
5. Bjarnason, J.B., Fish serine proteases and their pharmaceutical and cosmetic use. Patent: PCT, WO 00/78332 A2., 2000.
6. Bjarnason, J.B., A study to evaluate the inactivation of Avian H5N1 Influenza NIBRG-14 virus in the presence of 2 test articles at 2 time points, 2006.
7. Bjarnason, J.B., Determination of the antiviral efficacy of Zymetech test article, no. D-90203 against Influenza A/Panama/2007/99 (H3N2) virus on skin tissue, 2009.
8. Bjarnason, J.B., B. Asgeirsson, and J.W. Fox, Psychrophilic proteinases from Atlantic cod. Acs Symposium Series, 1993. 516: p. 69-82.
9. Bjarnason, J.B. and B. Benediktsson, Protein hydrolysates produced with the use of marine proteases. Patent: PCT, WO 01/28353 A2., 2001.
10. Gudmundsdottir, A., Cold-adapted and mesophilic brachyurins. Biol Chem, 2002. 383(7-8): p. 1125-31.
11. Guðmundsdóttir, Á. and J. Bjarnason, Applications of cold adapted proteases in the food industry, in Novel enzyme technology for food applications, R. Rastall, Editor 2007, Woodhead Publishing Limited, Cambridge, UK. p. 205-214.
12. Gudmundsdottir, A., et al., Isolation and characterization of cDNAs from Atlantic cod encoding two different forms of trypsinogen. Eur J Biochem, 1993. 217(3): p. 1091-7.
13. Gudmundsdottir, A. and H.M. Palsdottir, Atlantic cod trypsins: from basic research to practical applications. Mar Biotechnol (NY), 2005. 7(2): p. 77-88.
14. Gudmundsdottir, E., et al., Isolation and characterization of two cDNAs from Atlantic cod encoding two distinct psychrophilic elastases. Comp Biochem Physiol B Biochem Mol Biol, 1996. 113(4): p. 795-801.
15. Guthmundsdottir, A., et al., Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen. Biochim Biophys Acta, 1994. 1219(1): p. 211-4.
16. Hilmarsson, H., et al., Virucidal activity of Penzyme against Herpes simplex virus type 1, 2012. Manuscript submitted.
17. Kristjansdottir, S. and A. Gudmundsdottir, Propeptide dependent activation of the Antarctic krill euphauserase precursor produced in yeast. Eur J Biochem, 2000. 267(9): p. 2632-9.
18. Kristjansson, M.M., B. Asgeirsson, and J.B. Bjarnason, Serine proteinases from cold-adapted organisms. Adv Exp Med Biol, 1997. 415: p. 27-46.
19. Palsdottir, H.M. and A. Gudmundsdottir, Development of a qRT-PCR assay to determine the relative mRNA expression of two different trypsins in Atlantic cod (Gadus morhua). Comp Biochem Physiol B Biochem Mol Biol, 2007. 146(1): p. 26-34.
20. Palsdottir, H.M. and A. Gudmundsdottir, Expression and purification of a cold-adapted group III trypsin in Escherichia coli. Protein Expr Purif, 2007. 51(2): p. 243-52.
21. Palsdottir, H.M. and A. Gudmundsdottir, The novel trypsin Y from Atlantic cod (Gadus morhua) - isolation, purification and characterisation. Food Chemistry, 2008. 111: p. 408-414.
22. Spilliaert, R. and A. Gudmundsdottir, Atlantic Cod Trypsin Y-Member of a Novel Trypsin Group. Mar Biotechnol (NY), 1999. 1(6): p. 598-607.
23. Spilliaert, R. and A. Gudmundsdottir, Molecular cloning of the Atlantic cod chymotrypsinogen B. Microb Comp Genomics, 2000. 5(1): p. 41-50.
24. Stefansson, B., J.B. Bjarnason, and A. Gudmundsdottir, Ability of cod trypsin in degrading proteins in their native form, 2012. Manuscript submitted.
25. Stefansson, B., et al., Characterization of cold-adapted Atlantic cod (Gadus morhua) trypsin I - Kinetic parameters, autolysis and thermal stability. Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology, 2010. 155(2): p. 186-194.
26. Gudmundsdottir, A.S., B.; Bjarnason, J, Trypsin I in fish. Handbook of Proteolytic Enzymes, ed. N.S. Rawlings, G 2012. In press.

Documents